She certainly¹ has her hands full with four kids² in the house. 家里养着四个孩子,她当然忙得团团转.

have your hands full: to be very busy or too busy to do something else 忙得不可开交;应接不暇

It's no use asking Alice for help, she's got³ her hands full looking after the kids. Alice正照顾孩子忙得团团转,你找她帮忙只会是徒劳.

His hands are quite full enough without having me around. 没有我在身边,他忙得够呛.

I can't help you next week, I've got too much on my plate. 我下周不能帮你了,我自己的工作一大堆.

have enough/a lot/too much on your plate: to have a lot of work or problems⁴, etc. to deal⁵ with 问题(或工作等)成堆

I'm sorry I can't be of help. I have enough on my plate. 对不起,我不能提供帮助.我自顾不暇.