What are you up to?

这句常用句的意思是：最近在忙什么?

A: I haven't seen you around lately. What are you up to?

A: 最近没见到你。 在忙什么呢?

B: I'm working two jobs right now. It's killing¹ me.

B: 我现在做两份工作。很累很累!

"It's killing me." 是表示某事很折腾人的意思。

再如"Her singing is killing me." 她的歌声很难听!。